Fisetin Inhibits Listeria monocytogenes Virulence by Interfering With the Oligomerization of Listeriolysin O
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چکیده
منابع مشابه
Fisetin inhibits Listeria monocytogenes virulence by interfering with the oligomerization of listeriolysin O.
Listeriolysin O (LLO), an essential virulence determinant of Listeria monocytogenes, is a pore-forming toxin whose primary function is to facilitate cytosolic bacterial replication by breaching the phagosomal membranes, which is critical for the pathogen to evade host immune recognition. The critical role of LLO in the virulence of L. monocytogenes renders it an ideal target for designing novel...
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TO THE EDITOR—We read with great interest the recent publication by Wang et al about the direct interference of the flavonoid fisetin with the activity of the poreforming toxin listeriolysin O (LLO) from Listeria monocytogenes, which results in reduced virulence of the pathogen [1]. Recently, we found that pretreatment of the murine macrophages cell line P388D1 with fisetin prior to L. monocyto...
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Most human listeriosis outbreaks are caused by Listeria monocytogenes evolutionary lineage I strains which possess four exotoxins: a phosphatidylinositol-specific phospholipase C (PlcA), a broad-range phospholipase C (PlcB), listeriolysin O (LLO) and listeriolysin S (LLS). The simultaneous contribution of these molecules to virulence has never been explored. Here, the importance of these four e...
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Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores. Some effects of the toxins are observed in non-lytic concentrations. Two pathogens, Streptococcus pneumoniae and Listeria monocytogenes, cause fatal bacterial meningitis, and ...
متن کاملListeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule.
Infection of mice with Listeria monocytogenes caused marked lymphocyte apoptosis in the white pulp of the spleen on day 2 postinfection. We prove in this study that listeriolysin O (LLO), a pore-forming molecule and a major virulence factor of Listeria, could directly induce murine lymphocyte apoptosis both in vivo and in vitro at nanomolar and subnanomolar doses. Induction of apoptosis by LLO ...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2014
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiu520